منابع مشابه
Antifungal chemotherapeutics.
This review addresses trends in outcome and risk factors for invasive fungal infections, current antifungal agents and new therapeutic strategies. Current prospects for new therapies rest upon caspofungin, the first of a new class of antifungal molecules, the echinocandins, and new extended-spectrum azoles, voriconazole, posaconazole and ravuconazole. Approval by the Food and Drug Administratio...
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Bacterial infections represent an increasing worldwide threat. The number of untreatable diseases decreased after the 1950s due to the introduction of antimicrobial agents. However, since the 1980s, morbidity has risen again, and mortality due to respiratory infections, AIDS and tuberculosis now represents about 85% of world mortality from infections [1,2]. The increase in the number of new inf...
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Targeted delivery of chemotherapeutics is defined in the sense, that is, to maximize the therapeutic index of a chemotherapeutic agent by strictly localizing its pharmacological activity to the site or tissue of action. Integrins are a family of heterodimeric transmembrane glycoproteins involved in a wide range of cell-to-extracellular matrix (ECM) and cell-to-cell interactions. As cell surface...
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Human organic anion transporter 4 (hOAT4) belongs to a family of organic anion transporters which play critical roles in the body disposition of clinically important drugs. hOAT4 is expressed in the kidney and placenta. In the current study, we examined the inhibitory effects of 101 anticancer drugs from a clinical drug library on hOAT4 transport activity. The studies were carried out in hOAT4-...
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Malignant mesothelioma (MM) is a fatal disease in dire need of therapy. The role of inflammasomes in cancer is not very well studied, however, literature supports both pro-and anti-tumorigenic effects of inflammasomes on cancer depending upon the type of cancer. Asbestos is a causative agent for MM and we have shown before that it causes inflammasome priming and activation in mesothelial cells....
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 1952
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi1947.72.7_884